. 2019 Oct 22;63(11):e01293-19. doi: 10.1128/AAC.01293-19

TABLE 4.

MIC values for colonies obtained from antibiotic-containing agar plates at 0 and 120 h for each dosage regimen^a

Treatment	Meropenem at 15 mg/liter			Tobramycin at 7.5 mg/liter
	Time (h)	MIC (mg/liter)		Time (h)	MIC (mg/liter)
	Time (h)	Planktonic bacteria	Biofilm bacteria	Time (h)	Planktonic bacteria	Biofilm bacteria
Control	0	16	8	0	16	8
	120	32	16	120	32	16
MER at 2 g every 8 h	120	128	32	—	—	—
MER at 2 g every 8 h	120	128	32	—	—	—	MER at 6 g/day as a CI	120	64	32	—	—	—
MER at 6 g/day as a CI (60% ELF penetration)	120	16	NC	—	—	—	MER at 6 g/day as a CI	120	64	32	—	—	—
MER at 6 g/day as a CI (60% ELF penetration)	120	16	NC	—	—	—	TOB at 10 mg/kg every 24 h	—	—	—	120	64	32
MER at 2 g every 8 h + TOB at 10 mg/kg every 24 h	120	64	32	120	32	32	TOB at 10 mg/kg every 24 h	—	—	—	120	64	32
MER at 2 g every 8 h + TOB at 10 mg/kg every 24 h	120	64	32	120	32	32	MER at 6 g/day as a CI + TOB at 10 mg/kg every 24 h	120	32	16	120	32	16
MER at 6 g/day as a CI (60% ELF penetration) + TOB at 10 mg/kg every 24 h	120	NC	NC	120	NC	NC	MER at 6 g/day as a CI + TOB at 10 mg/kg every 24 h	120	32	16	120	32	16

The agar plates contained meropenem (MER) at 15 mg/liter and tobramycin (TOB) at 7.5 mg/liter. NC, no colonies grew on the antibiotic-containing plates; —, not tested.