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Optimal initial amikacin dose (OIAD) targeting a maximal concentration in plasma (Cmax)/MIC ratio of ≥8 as a function of body surface area (BSA) and creatinine clearance estimated by the Cockcroft-Gault formula (CLCG) for MIC values of 8 mg/liter (top), 4 mg/liter (center), and 2 mg/liter (bottom). Note that the maximal dose was capped at 5 g.
