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Population pharmacokinetic parameters of the final model
| Pharmacokinetic parameter | Mean | Coefficient of variation (%) | Median | Rangeb |
|---|---|---|---|---|
| Typical clearance (CL0 [liters/h]) | 2.6 | 53.4 | 2.6 | 0.7–9.9 |
| Typical central volume of distribution (V10 [liters])a | 23.0 | 44.8 | 20.7 | 10.3–69.7 |
| Intercompartment clearance (Q [liters/h]) | 0.5 |
Of note, we set the peripheral volume V2 equal to V1.
Minimum and maximum values are given.
