TABLE 1.
Plasma pharmacokinetic parameters of manogepix in uninfected, neutropenic mice following 7 days of administration with the prodrug fosmanogepix
| Pharmacokinetic parametera | Values by fosmanogepix dose |
|||
|---|---|---|---|---|
| 78 mg/kg TID | 130 mg/kg TID | 260 mg/kg BID | 260 mg/kg TID | |
| Cmax (μg/ml) | 6.82 | 6.97 | 49.0 | 44.9 |
| Tmax (h) | 0.5 | 1.0 | 0.5 | 0.5 |
| Half-life (h) | 0.9 | 1.1 | 1.7 | 2.0 |
| AUC0-last (μg·h/ml) | 11.3 | 13.5 | 52.7 | 58.0 |
| AUC0-inf (μg·h/ml) | 11.3 | 13.6 | 52.8 | 58.4 |
| Calculated total daily exposures, AUC0-inf (μg·h/ml) | 33.9 | 40.8 | 105.6 | 175.2 |
a
Cmax, maximum concentration of drug in serum; Tmax, time to maximum concentration of drug in serum; AUC0-last, area under the concentration-time curve from 0 h to last time point.