TABLE 2.
Changes in fungal CFU per gram of tissues for each treatment group compared with that prior to the start of therapy in both study arms
| Treatment group | Log10 changea
(95% CI) in fungal CFU/g by study arm and tissue type |
|||
|---|---|---|---|---|
| Fungal burden |
Survival |
|||
| Kidney | Brain | Kidney | Brain | |
| Vehicle control | 0.80 (−1.46 to 3.07) | 0.68 (−0.92 to 2.28) | 1.85 (−0.10 to 3.81) | 1.80 (−0.11 to 3.72) |
| Fosmanogepix, 104 mg/kg TID | −0.50 (−2.76 to 1.76) | 0.13 (−1.47 to 1.73) | −1.52 (−3.47 to 0.44) | −1.46 (−3.37 to 0.46) |
| Fosmanogepix, 130 mg/kg TID | 0.69 (−2.95 to 1.57) | 0.06 (−1.54 to 1.66) | −1.50 (−3.46 to 0.46) | −1.29 (−3.20 to 0.63) |
| Fosmanogepix, 260 mg/kg BID | −0.94 (−3.20 to −1.32) | −0.73 (−2.33 to 0.87) | −1.57 (−3.53 to 0.38) | −1.44 (−2.29 to 0.51) |
| Fluconazole, 20 mg/kg QD | 1.08 (−1.18 to 3.34) | 1.19 (−0.42 to 2.78) | 2.11 (0.15 to 4.07) | 2.05 (0.13 to 3.96) |
| Caspofungin, 10 mg/kg QD | −1.39 (−3.65 to 0.87) | 0.63 (−0.96 to 2.23) | −2.78 (−4.74 to −0.82) | −1.86 (−3.78 to 0.05) |
a
All values are compared with that of the 24-h control.