Target attainment rates by MIC of free piperacillin concentrations for 50% of the dosing interval in 1,000 simulated children ages 2 to 6 months (A) and 6 months to 6 years (B). The solid horizontal black lines represent the 90% target attainment rate. q4h, q6h, and q8h, every 4, 6, and 8 h, respectively.