TABLE 3.

Final tazobactam model and bootstrap^a

Parameter	Final model				Bootstrap analysis (n = 1,000)
	Point estimate	RSE (%)	95% CI	Shrinkage (%)	2.5th percentile	Median	97.5th percentile
Typical value
CL (liters/h)	3.15	12.7	2.37 to 3.93		2.34	3.10	4.15
Vc (liters)	3.79	19.7	2.33 to 5.25		2.25	3.69	5.97
Q (liters/h)	0.20	45.0	0.02 to 0.38		0.06	0.20	0.48
Vp (liters)	3.65	46.6	0.32 to 6.98		0.30	3.19	7.85
Covariate effect
WT on CL and Q (exponent)	1.24	16.1	0.85 to 1.62		0.77	1.24	1.69
Furosemide on CL	−0.29	66.3	−0.66 to 0.09		−0.55	−0.30	−0.04
WT on Vc and Vp (exponent)	1.06	31.4	0.41 to 1.71		0.30	1.09	1.85
Variance model
IIV (CL)	0.37	19.8	0.23 to 0.52	6	0.23	0.37	0.51
IIV (Vc)
IIV (Vp)
IIV (Q)
Proportional error	0.43	10.1	0.34 to 0.52	16	0.11	0.17	0.24

^aCI, confidence interval; CL, clearance; IIV, interindividual variability; Q, intercompartmental clearance; RSE, residual standard error; V_c, volume of distribution of the central compartment; V_p, volume of distribution of the peripheral compartment; WT, body weight.