TABLE 1.
Dalbavancin concentrations in ELF and plasma
| Parameter | Dalbavancin concn (μg/ml) at (h): |
||||||
|---|---|---|---|---|---|---|---|
| 4 | 8 | 12 | 24 | 72 | 120 | 168 | |
| Plasma (median [SD])a | 279 (32) | 222 (27) | 194 (24) | 169 (20) | 120 (14) | 94 (11) | 79 (9) |
| Calculated unbound plasma (median)b | 20 | 16 | 14 | 12 | 8 | 7 | 6 |
| ELF (median; mean [SD])c | 1.9; 1.9 (1.0) | 2.2; 3.1 (1.9) | 2.8; 3.6 (2.1) | 2.6; 2.7 (0.5) | 4.2; 7.3 (8.2) | 3.3; 11.9 (20.1) | 2.1; 2.0 (0.6) |
a
All 37 subjects had plasma values measured at 0.5 h (442 [51] μg/ml), 1 h (397 [48] μg/ml), and 2 h (331 [42] μg/ml), in addition to the times shown.
b
93% protein binding (unbound fraction, 7%).
c
ELF was obtained from 5 subjects at each time point.