FIG 4.

(A to C) Expression levels of genes encoding ABC and MFS transporters, as determined by qRT-PCR, in the absence of azole (A), upon exposure to itraconazole (ITC) (B), and upon exposure to voriconazole (VRC) (C). T. rubrum strains CHUV1845 and TIMM20092 were cultured for 7 days in SDB without an antifungal drug or SDB containing subinhibitory concentrations of ITC or VRC. The fold change represents the level of gene expression compared with that of T. rubrum CHUV1845 grown in SDB without antifungal drugs. The bars represent the standard deviation of the data obtained from three independent experiments. ***, P < 0.001.