TABLE 1.
Identification of potential T. rubrum MFS transporters involved in azole resistance
| Locus name by organism | Transporter name(s)/synonyms | Resistance(s)or substrate informationa | PMID (reference) | T. rubrum homolog(s)c | Protein sequence identity, length of identical parts of proteins (aa)b |
|---|---|---|---|---|---|
| A. fumigatus | |||||
| AFUA_1G13800 | mdrA | VRC and FLC | 26933209 (21) | TERG_08336 (TruMFS2) | 64.4, 595 |
| AFUA_1G15490 | mfsB | VRC induced | 16622700 (22) | TERG_07418 | 65.1, 578 |
| AFUA_4G10000 | mdr3 | ITC induced | 15563516 (23) | TERG_06399 | 77.8, 803 |
| AFUA_1G12620 | aflT | Not aflatoxin | 17620135 (24) | TERG_01623 (TruMFS1) | 53.2, 494 |
| C. albicans | |||||
| CAALFM_CR04210CA | QDR1 | Not azoles | 24621232 (62) | TERG_04280 | 28.1, 509 |
| CAALFM_C305570WA | QDR2 | Not azoles | 24621232 (62) | TERG_04280 | 29.2, 504 |
| CAALFM_C601290CA | QDR3 | Not azoles | 24621232 (62) | TERG_00820 | 45.8, 697 |
| CAALFM_C701520WA | FLU1/TPO1 | Mycophenolic acid, FLC | 11065353 (63) | TERG_04626 | 49.5, 610 |
| CAALFM_C603170CA | MDR1/BMR1/BEN1 | Benomyl, CYH, methotrexate, FLC | 8031026 (64), 9210670 (65), 15273122 (66), 10844673 (67), 11568478 (68) | TERG_05582 | 35.2, 564 |
| CAALFM_C604610CA | NAG3/MDR97/TMP1 | CYH | 12076781 (69) | TERG_07884 | 56.4, 561 |
| CAALFM_C604620CA | NAG4 | CYH | 12076781 (69) | TERG_07884 | 57.1, 581 |
| C. glabrata | |||||
| CAGL0J09944g | AQR1 | Acetic acid, flucytosine, CLT | 23805133 (70) | TERG_04280 | 30.6, 492 |
| CAGL0G08624g | QDR2 | Quinidine, MICO, TIC, CLT, KTC | 23629708 (71) | TERG_04280 | 30.1, 583 |
| CAGL0G03927g | TPO1_1 | CLT | 26512119 (72) | TERG_04626 | 42.7, 518 |
| CAGL0E03674g | TPO1_2 | CLT | 26512119 (72) | TERG_04626 | 48.3, 478 |
| CAGL0H06017g | FLR1 | 5-Flucytosine | 28066366 (73) | TERG_05582 | 35.5, 512 |
| CAGL0H06039g | FLR2 | 5-Flucytosine | 28066366 (73) | TERG_05582 | 35.7, 566 |
| CAGL0I10384g | TPO3 | CLT, MICO, KTC, FLC | 24576949 (74) | TERG_07884 | 41.2, 450 |
a
Compounds that are found to be substrates or to induce gene expression and those that are not substrates are indicated. ITC, itraconazole; VRC, voriconazole; FLC, fluconazole; MICO, miconazole; TIC, tioconazole; CLT, clotrimazole; KTC, ketoconazole; CYH, cycloheximide.
b
aa, amino acids.
c
The efflux pumps conferring drug resistance are named between parentheses and highlighted in bold.