TABLE 3.
Characterization of potential T. rubrum transporters involved in azole resistance
| Locus name by type | Transportera name | Resistance for azoleb: |
Commentsc | |||||
|---|---|---|---|---|---|---|---|---|
| VRC | ITC | KTC | FLC | MIC | CYH | |||
| ABC transporters | ||||||||
| TERG_02508 | TruMDR1 | + | − | − | + | + | − | Close to A. fumigatus, C. albicans, and C. glabrata azole transporters |
| TERG_08613 | TruMDR2 | − | + | − | − | − | − | Close to A. fumigatus mdr1 |
| TERG_02186 | TruMDR3 | + | + | + | + | + | − | Close to A. fumigatus, C. albicans, and C. glabrata azole transporters |
| TERG_07801 | TruMDR4 | − | − | − | − | − | − | Close to A. fumigatus mdr4 |
| TERG_04952 | TruMDR5 | − | + | − | − | − | − | Close to A. fumigatus abcE |
| TERG_01443 | − | − | − | − | − | − | − | Close to A. fumigatus abcB |
| TERG_08591 | − | − | − | − | − | − | − | Close to A. fumigatus mdr1 |
| TERG_08751 | − | − | − | − | − | − | − | Close to A. fumigatus mdr1 and abcE |
| MFS transporters | ||||||||
| TERG_01623 | TruMFS1 | + | + | + | + | + | + | Close to A. fumigatus aflatoxin transporter aflT |
| TERG_08336 | TruMFS2 | + | − | − | + | − | − | Close to A. fumigatus mdrA |
| TERG_07418 | − | − | − | − | − | − | − | Close to A. fumigatus mfsB |
| TERG_06399 | − | − | − | − | − | − | − | Close to A. fumigatus mdr3 |
| TERG_04626 | − | − | − | − | − | − | − | Close to C. albicans FLU1 and C. glabrata TPO1_1 and TPO1_2 |
| TERG_07884 | − | − | − | − | − | − | − | Close to C. albicans MDR1 and C. glabrata FLR1 and FLR2 |
| TERG_05582 | − | − | − | − | − | − | − | Low similarities with C. albicans NAG3 and NAG4 and C. glabrata TPO3 |
| TERG_04280 | − | − | − | − | − | − | − | Low similarities with C. albicans QDR1 and QDR2 and C. glabrata AQR1 and QDR2 |
| TERG_00820 | − | − | − | − | − | − | − | Low similarities with C. albicans QDR3 |
a
Only transporters showing azole transporter activity have been named. The others are marked with a minus sign.
b
+, Constructs showing resistance in S. cerevisiae; −, no resistance.
c
Close homologs from A. fumigatus and/or Candida spp. are indicated.