Table 3.

Various applications of iron oxide nanoparticles in cancer detection and therapy

Nanosystem	Target molecule/drug	Cell line/animals	Application	Result	References
IONPs	FA	KB cells and Nude BALB/c female mice	MRI	It shows great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy	Vu-Quang et al. (2019)
IONPs	DOX		In vivo imaging and anti-tumor activity experiments	Realize the diagnosis and treatment of malignant tumor at the same time	Jie et al. (2019)
IONPs	10-hydroxy camptothecin, HCPT	MCF-7, 3T3, 4T1 cell lines and BALB/c mice	Contrast agent for MR imaging, PTT and chemotherapy	IONPs elicits the generation of ROS with the presence of macrophage, which can further inhibit the growth of cancer cell	Li et al. (2019b)
IONPs	DOX	–	MR contrast agent	Theragnostic application due to low toxicity, MRI character, passive and magnetic targeting properties.	Kim et al. (2018)
Egg albumin coated IONPs	5- Fluorouracil	L-929 fibroblast cells	Swelling control and magnetic field mediated drug delivery	Release behavior of drug depends on swelling ratio, pH, temperature and simulated fluids	Sonker et al. (2018)
IO/carbon NPs	hydroxypropyl-β-cyclodextrin, DOX	4T1 cells	MR/NIRFL dual-modal imaging	NIR induced heat also increases the drug permeation. Tumor inhibition was recorded due to synergetic chemo/PT therapy	Song et al. (2018)
Cobalt IONPs	FA, DOX	Peripheral blood mononuclear cells (PBMC)	Magnetic field- induced hyperthermia	Drug release increases at higher temperature and acidic pH. Synthesized nanoconjugate was biocompatible in nature	Dey et al. (2018)