Table 2.

The roles of the mutually dysregulated miRNAs in HCC and CSC, in MSC differentiation.

miRNA	Role in MSCs
miR-let-7 family	Inhibits adipogenesis and migration of cells (Sung et al., 2013)
miR-16	Enhances myogenesis and G1 arrest (Liu et al., 2012; Wang et al., 2012)
miR-17	Enhances osteogenesis (Liu Y. et al., 2011)
miR-20a	Enhances osteogenesis (Zhang et al., 2011)
miR-21	Enhances both osteogenesis and adipogenesis but inhibits proliferation and aids in survival under hypoxic conditions (Nie et al., 2011; Kim et al., 2012; Mei et al., 2013)
miR-24	Enhances adipogenesis and inhibits osteogenesis (Sun et al., 2009; Hassan et al., 2010)
miR-27a	Inhibits osteogenesis (Schoolmeesters et al., 2009; Hassan et al., 2010)
miR-141	Inhibits osteogenesis (Itoh et al., 2009)
miR-145	Inhibits chondrogenesis (Tong et al., 2011; Martinez-Sanchez et al., 2012)
miR-155	Inhibits adipogenesis and immune regulation (Skårn et al., 2012; Xu C. et al., 2013)
miR-194	Inhibits chondrogenesis (Xu et al., 2012)
miR-200a	Inhibits osteogenesis (Thurnherr et al., 2016)
miR-221	Inhibits adipogenesis (El-Halawany et al., 2015)
miR-222	Inhibits adipogenesis (El-Halawany et al., 2015)