Table 3.
The relationship among miRNAs' expression, target genes' expression, and the fate of HCC.
| miRNA | Expression | Target genes | Expression of target genes | Fate of HCC |
|---|---|---|---|---|
| miR-Let-7a | ||||
| miR-Let-7b | ||||
| miR-Let-7c | ||||
| miR-Let-7d | RAS oncogenes | Suppression | ||
| miR-Let-7e | ||||
| miR-Let-7f | ||||
| miR-Let-7g | ||||
| miR-200 a | Foxa2 | Enhanced proliferation and carcinogenesis | ||
| miR-200 b | Downregulation | BMI1 | Upregulation | |
| miR-145 | ROCK 1 | Increased tumorigenesis and invasion | ||
| miR-34a | HDAC1 | Inhibition of invasion and migration | ||
| miR-141 | TIAM1 | Inhibition of proliferation, invasion, and migration | ||
| miR-7 | CDR1 | Suppression | ||
| miR-424 | C-myb | Inhibition of invasion and proliferation | ||
| miR-9 | PPAR alpha | Increase growth and metastasis | ||
| miR-16 | Bcl-2 | Inhibition of proliferation, invasion, and metastasis | ||
| miR-17 | TSP 1 | Increased tumorigenesis | ||
| miR-18 | SMAD2 | Inhibition of migration | ||
| miR-20a | MCl-1 | Increased proliferation and recurrence | ||
| miR-21 | KLFS | Increased progression and metastasis | ||
| miR-24 | P53 | Increased Metastasis and invasion | ||
| miR-27a | PPAR-y | Increased proliferation | ||
| miR-495 | IGFlR | Inhibition of proliferation and invasion | ||
| miR-191 | Upregulation | TIMP3 | Downregulation | Increased proliferation and tumorigenesis |
| miR-155 | Oncogenesis and casein kinase 1-α (CK1-α) | Increased proliferation and tumorigenesis and decreased apoptosis | ||
| miR-221 | NFkB and downstream genes such as (bcl-2/MMP-9 and VEGF) | Increased proliferation and tumorigenesis | ||
| miR-22 | 3UTR of CD147 | – | ||
| miR-210 | SMAD4-STAT6 | Increased angiogenesis | ||
| miR-1246 | Downregulated | CADM1 | Upregulated | Increased migration |
| miR-29c | Downregulated | SIRT 1 | Upregulated | Suppression |
| miR-214 | Downregulated | CTNNB 1 | Upregulated | Suppression |
| miR-215 | Downregulated | Upregulated | Suppression | |
| miR-142 | Downregulated | THBS4–TGF-β | Upregulated | Increased migration, invasion, and metastasis |
| miR-150 | Downregulated | GAB1 | Upregulated | Suppression |
| miR-93 | Upregulated | PDCD 4 | Downregulated | Increased migration and invasion |
| miR-183 | Upregulated | ETS2 and EGR1 | Downregulated | Carcinogenesis |
| miR-185 | Downregulated | DNTM1 | Upregulated | Increased proliferation |
| miR-194 | Downregulated | MAP4K4 | Upregulated | Increased proliferation |
| miR-101 | Downregulated | 3′UTR of WT-PTEN | Upregulated | Promotion of apoptosis and suppression |