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. 2019 Oct 17;9:356. doi: 10.3389/fcimb.2019.00356

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Copyright © 2019 Chen, Rathod, Chiu, Chen, Tsai and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inactivation of lrp resulted in increased inflammation in vivo. (A) Representative gross views of the cecum and colon from uninfected mice or mice infected with different strains of C. difficile. (B) Quantification of normalized reduction in cecum weight as an indication of cecum inflammation. (C) Representative colon sections stained with hematoxylin and eosin. (D) Periodic Acid-Schiff stain. (Magnification × 40 and × 20; scale bar, 5 μm for dimensional comparison between images. The results were analyzed by one-way analysis of variance and Dunnett's multiple—comparison test (ns, not significant; ^****p < 0.0001).