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. 2019 Oct 23;10:4814. doi: 10.1038/s41467-019-12736-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Reduced FS IN–SC connectivity in Fmr1-KO, but no change in connection properties. a Monosynaptic connection probability between pairs of FS and SCs tested with paired whole-cell recording. Asterisks: p < 0.05, Chi-squared test. b, c Connection strengths (b), peak evoked monosynaptic current amplitude and current onset latencies (c) for connected pairs shown in (a). No differences in connection strength between genotype were observed for either connection direction (p > 0.05, Mann–Whitney, N’s as in (a)). d Monosynaptic connection probability between pairs of SCs located within the same barrel for recordings in slices taken from P10–11 mice of each genotype. No change in connection probability was observed (p > 0.05, Chi-squared test). Not shown: Significant reduction in SC–SC connectivity for Fmr1^−/Y at P12–15 (37/110, 8/54 tested pairs connected for Fmr1^+/Y and Fmr1^−/Y, respectively, χ2(1) = 7.78, p < 0.01). e, f No change in synaptic strengths (e) or peak monosynaptic EPSC amplitude (f) between the connected SC pairs from P10–11 Fmr1^+/Y and Fmr1^−/Y littermate mice shown in (d) (p > 0.05, Mann–Whitney, N’s as in (a))