Table 15.
Physicochemical properties of L1 and L2 DNA vaccine constructs.
| construct | Epitope sequence (HPV-Type) | Antigenicity* | Molecular weight (Da) | Instability index of constructs | Solubility index of constructs** | In vivo half time |
|---|---|---|---|---|---|---|
| L1 | EATVYLPPVPVSKVVA (16) | 0.5397 | 28227 | 47.52(stable) | 0.648(soluble) | >20 hours |
| DNTVYLPPPSVARV (18) | 0.2280 | |||||
| DTYRFVTSQAIACQK (16) | 0.1995 | |||||
| DTYRFVQSVAITCQK (18) | 0.3133 | |||||
| YLPPVPVSKV (16) | 1.0876 | |||||
| YLPPPSVARV (18) | 0.4104 | |||||
| DQFPLGRKFLL (16) | 0.2797 | |||||
| DQYPLGRKFLV (18) | 0.6476 | |||||
| L2 | PDFLDIVALHRPALTSR (16) | 1.1115 | 25674 | 34.01(Stable) | 0.407(soluble) | >20 hours |
| SDFMDIIRLHRPALTSR (18) | 0.4570 | |||||
| FFGGLGIGTGSGTGGR (16) | 1.0724 | |||||
| DPSIVTLIEDSSVVTSGAP (18) | 0.4474 | |||||
| KRASATQLYK (16) | 0.1484 | |||||
| KRASVTDLYK (18) | 0.4778 | |||||
| DPDFLDIVALHR (16) | 1.6210 | |||||
| DSDFMDIIRLHR (18) | 0.3371 |
*higher rate shows high degree of peptide antigenicity.
**higher rate shows high degree of peptide solubility.