Table 4.
Overall survival analyses according to preoperative PDW in 495 patients with ESCC.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| PDW (≥13.4 vs. <13.4) | 5.111 | 3.101–8.425 | <0.001 | 1.194 | 1.120–1.273 | <0.001 |
| Sex (male vs.female) | 1.676 | 0.845–3.326 | 0.139 | |||
| Age (>60 vs. ≤60) | 1.238 | 0.833–1.838 | 0.291 | |||
| Depth of tumor | ||||||
| T1a–1b | 0.296 | 0.093–0.937 | 0.038 | 0.447 | 0.116–1.722 | 0.242 |
| T2 | 0.607 | 0.355–1.038 | 0.607 | 0.435 | 0.135–1.399 | 0.162 |
| T3 | 1.000 | 1.000 | ||||
| Lymph node metastasis | ||||||
| N0 | 0.112 | 0.056–0.222 | <0.001 | 0.073 | 0.015–0.363 | 0.001 |
| N1 | 0.308 | 0.164–0.576 | <0.001 | 0.331 | 0.168–0.650 | 0.001 |
| N2 | 0.432 | 0.219–0.855 | 0.016 | 0.486 | 0.240–0.985 | 0.045 |
| N3 | 1.000 | 1.000 | ||||
| Pathological stage | ||||||
| 1a–1b | 0.194 | 0.084–0.447 | <0.001 | 2.384 | 0.184–30.799 | 0.506 |
| 2a–2b | 0.395 | 0.251–0.623 | <0.001 | 1.556 | 0.386–6.283 | 0.534 |
| 3a–3c | 1.000 | 1.000 | ||||
| Vessel invasive (absence vs. presence) | 1.793 | 1.197–2.686 | 0.005 | 1.098 | 0.704–1.713 | 0.681 |
| Nerve infiltration (absence vs. presence) | 1.990 | 1.343–2.948 | 0.001 | 1.855 | 1.214–2.836 | 0.004 |
| Treatment regimen | ||||||
| S | 1.425 | 0.656–3.099 | 0.371 | |||
| S plus postoperative C | 1.430 | 0.611–3.348 | 0.410 | |||
| S plus postoperative CRT | 1.000 | |||||
| Hospital time (days) (>14 vs. ≤14) | 1.811 | 1.169–2.803 | 0.008 | 1.828 | 1.159–2.881 | 0.009 |
| Platelet | 0.996 | 0.992–0.999 | 0.018 | 1.000 | 0.996–1.004 | 0.904 |
| Albumin | 0.931 | 0.884–0.981 | 0.007 | 0.947 | 0.892–1.006 | 0.076 |
| RDW | 1.258 | 1.016–1.557 | 0.035 | 1.072 | 0.838–1.370 | 0.579 |
| Aspartate transaminase | 0.995 | 0.972–1.019 | 0.709 | |||
| Fibrinogen | 1.137 | 0.909–1.422 | 0.262 | |||
| Hemoglobin | 0.831 | 0.729–0.948 | 0.006 | 0.853 | 0.726–1.002 | 0.053 |
Abbreviations: S, surgery; C, chemotherapy; CRT, chemoradiotherapy; PDW, platelet distribution width; RDW, red cell distribution width.