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. 2019 Oct 23;9:15246. doi: 10.1038/s41598-019-51608-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Burrowing assay phenotypes C. elegans models of neurodegenerative diseases. (a) Burrowing performance of day 1 adults polyQ strains with glutamine expansions in muscles, α-synuclein-expressing strain and wild-type animals. P-values are 0.1268, 0.0302 and 0.0016 for strains expressing Q35, Q40 and α-synuclein respectively. N = 34, 39, 41 and 43 animals for WT, Q35, Q40 and α-synuclein strains, respectively. (b) Images show visible protein aggregates in the Q40-expressing strain and not in the Q35-expressing strain. (c) Day 1 adult Q67-expressing and Q86-experssing animals with protein aggregation in neurons are deficient in burrowing. P-values for Q67: <0.0001, Q86: 0.0437. Data was collected from 6 replicates. N = 37, 37 and 38 animals for WT, Q67 and Q86 strains respectively. Assay conditions are 26% w/w, H = 0.7 cm and 100 mg/mL E. coli.