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. 2019 Oct 23;10:4812. doi: 10.1038/s41467-019-12670-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Context-dependent encoding during learning and dependence on M2 input. a Expression of the DREADD system in M2 L2/3 and L5 (hM4Di receptor and mCherry). Temporal development of grasp type frequency (b), joint flexibility demands (c), population coding (d), and population coding for twin grasps (e) during the naive (N), learning (L), expert (E), and expert M2-M1-silenced phase (S), and separately for the regular (cyan) and irregular (magenta) condition; mean ± s.d., n = 4. f Population coding according to joint flexibility demands during the naive, learning, expert and expert M2-M1-silenced phase, respectively (only twin grasps are considered). Note that context-dependent encoding according to joint flexibility demands emerges during learning and is disrupted after silencing of M2-M1 projections; asterisk indicates P < 0.05, linear regression with clustered standard error (robust); cluster variable = neuronal network