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. 2019 Oct 23;9:15224. doi: 10.1038/s41598-019-51665-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PA200 does not protect from bleomycin-induced lung fibrosis in mice. Lungs of PA200−/− and wildtype (WT) mice instilled with 2 U/kg body weight bleomycin (Bleo) or PBS as control were analyzed for the development of fibrosis at day 14. (a) Lung function analysis including resistance and compliance of wildtype (WT) and PA200−/− (KO) mice at day 14 after bleomycin (Bleo) or PBS instillation (Kruskal-Wallis test and Dunn’s multiple comparisons test, n = 11–16 per group). (b) Lungs of wildtype (WT) and PA200−/− (KO) mice 14 days after PBS- or bleomycin-instillation were analyzed for fibrotic marker collagen1α1 (Col1a1), fibronectin (Fn) and tenascin C (Tnc) mRNA expression by RTqPCR. Rpl19 served as housekeeping gene (Kruskal-Wallis test and Dunn’s multiple comparisons test, n = 12–17 per group; combined results from two independent animal experiments). (c) Representative hematoxylin & eosin staining of paraffin-embedded lung tissue sections at day 14 after bleomycin instillation.