Table 4.

Risk of bias of the included in vivo studies.

Study	A	B	C	D	E	F	G	H	I	J	Total
Deng and Lai 2013	√		√			√					3
Han, 2014	√	√	√			√					4
He et al., 2014	√	√	√	√		√			√	√	7
Yu et al., 2014	√		√	√		√				√	5
Xia et al., 2015	√	√	√	√		√			√	√	7
Yu et al., 2016	√	√	√	√	√	√			√	√	8
Tu et al., 2018	√	√				√			√	√	5
Meng et al., 2014	√	√	√		√	√			√	√	7
Zou et al., 2017	√	√	√			√			√		5
Wang et al., 2016	√	√				√			√	√	5
Zhao et al., 2017	√	√				√					3
Dong et al., 2015	√	√				√				√	4

Studies fulfilling the criteria of: A, peer reviewed publication; B, control of temperature; C, random allocation to treatment or control; D, blinded induction of model; E, blinded assessment of outcome; F, use of anesthetic without significant intrinsic vascular protection activity; G, appropriate animal model (aged, diabetic, or hypertensive); H, sample size calculation; I, compliance with animal welfare regulations; J, statement of potential conflict of interests.