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. 2019 Oct 17;10:939. doi: 10.3389/fgene.2019.00939

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Copyright © 2019 Cai, Long, Chong, Cai, Tsang, Zhou, Lin, Ding, Zhou, Zhao, Chen, Wang, Lyu, Cho and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EBV-miR-BART7-3p stimulates TGF-β signaling and induces the relocalization of p-SMAD2 and p-SMAD3 by suppressing SMAD7. (A) The expression of TGF-β-R1, SMAD2, p-SMAD2, SMAD3, and p-SMAD3 was detected by Western blot in indicated cells treated with lentiviral particles carrying EBV-miR-BART7-3p and their corresponding NCs, respectively. GAPDH served as the internal control. (B) Western blot analysis of endogenous SMAD7, p-SMAD2, p-SMAD3 protein expression levels in HK1-EBV and HONE1-EBV cells treated with anti-miR or anti-C. GAPDH served as the internal control. (C) Confocal analysis was used to compare the expression and nuclear accumulation of p-SMAD2 and p-SMAD3 between NC cells and BART7-3p NPC cells (Magnification, ×1200; scale bar, 5 um).