Figure 7.

EBV-miR-BART7-3p reduces the sensitivity of chemotherapeutic drugs of NPC cells. (A) Cell viabilities of either CNE2-BART7-3p or 5-8F-BART7-3p cells treated by three chemotherapy drugs (fluorouracil, cisplatin, paclitaxel) with varied density were determined by OD values. HK1-EBV cells transfected with anti-miR or anti-C cells were also measured. (B) Western blot analyses of SMAD7 and p-SMAD2/3 in indicated cells treated with cisplatin (5 mg/kg). (C) As the pictures shown, xenograft tumors contained CNE2-BART7-3p grew faster and bigger even under the condition of cisplatin (5 mg/kg) applied every 3 days after tumors grew to 10 mm, compared to NC. The volume or weigh of xenograft tumors were shown in the bar chart. (D) Western blot analyses of SMAD7 and p-SMAD2/3 in indicated cells extracted from xenograft tumors in nude mice. (**p < 0.01, ***p < 0.001)