Table 1.
Univariable repeated‐measures analyses: Longitudinal change in functional outcomes by treatment group for symptomatic knee osteoarthritis patients
| Treatment | Preprocedure | Postprocedure | p values | Change (pre–post) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean ± SEM | n | Mean ± SEM | Treat | Time | Treat by time | Mean change (95% CI) | p | ||
| VAS for pain | ||||||||||
| Pain | BMAC | 41 | 3.9 ± 0.355 | 40 | 2.5 ± 0.351 | .38 | <.01 | .89 | 1.502 (0.780, 2.223) | <.01 |
| MFAT | 35 | 4.3 ± 0.385 | 35 | 2.8 ± 0.376 | – | – | – | 1.411 (0.635, 2.186) | <.01 | |
| Emory quality of life | ||||||||||
| Mobility | BMAC | 39 | 1.694 ± 0.074 | 39 | 1.407 ± 0.080 | .45 | <.01 | .65 | 0.287 (0.103, 0.470) | <.01 |
| MFAT | 32 | 1.732 ± 0.082 | 32 | 1.508 ± 0.088 | – | – | – | 0.223 (0.019, 0.428) | .03 | |
| Self‐care | BMAC | 39 | 1.187 ± 0.057 | 39 | 1.050 ± 0.037 | .50 | .06 | .30 | 0.137 (0.015, 0.259) | .03 |
| MFAT | 32 | 1.102 ± 0.062 | 32 | 1.061 ± 0.041 | – | – | – | 0.041 (‑0.094, 0.176) | .55 | |
| Usual activities | BMAC | 39 | 1.646 ± 0.083 | 38 | 1.494 ± 0.094 | .05 | .02 | .65 | 0.152 (‑0.071, 0.375) | .18 |
| MFAT | 32 | 1.887 ± 0.091 | 32 | 1.659 ± 0.102 | – | – | – | 0.228 (‑0.016, 0.473) | .07 | |
| Pain/discomfort | BMAC | 39 | 2.056 ± 0.079 | 38 | 1.735 ± 0.089 | .28 | <.01 | .51 | 0.321 (0.129, 0.512) | <.01 |
| MFAT | 32 | 2.215 ± 0.087 | 32 | 1.799 ± 0.097 | – | – | – | 0.416 (0.205, 0.627) | <.01 | |
| Anxiety | BMAC | 39 | 1.210 ± 0.070 | 37 | 1.164 ± 0.079 | .24 | .49 | .98 | 0.047 (‑0.129, 0.222) | .60 |
| MFAT | 32 | 1.314 ± 0.077 | 32 | 1.271 ± 0.085 | – | – | – | 0.043 (‑0.148, 0.235) | .65 | |
| Composite | BMAC | 39 | 0.727 ± 0.027 | 37 | 0.835 ± 0.027 | .09 | <.01 | .98 | ‑0.108 (‑0.162, ‑0.054) | <.01 |
| MFAT | 32 | 0.667 ± 0.030 | 32 | 0.774 ± 0.029 | – | – | – | ‑0.107 (‑0.166, ‑0.047) | <.01 | |
| Knee Injury and Osteoarthritis Score | ||||||||||
| Pain | BMAC | 39 | 54.6 ± 2.674 | 40 | 70.6 ± 3.313 | .63 | <.01 | .56 | ‑16.0 (‑23.1, ‑8.9) | <.01 |
| MFAT | 34 | 51.4 ± 2.867 | 32 | 70.4 ± 3.692 | – | – | – | ‑19.1 (‑26.9, ‑11.2) | <.01 | |
| Symptoms | BMAC | 39 | 53.7 ± 2.992 | 40 | 69.4 ± 3.702 | .94 | <.01 | .61 | ‑15.7 (‑23.2, ‑8.1) | <.01 |
| MFAT | 34 | 54.9 ± 3.209 | 32 | 67.6 ± 4.120 | – | – | – | ‑12.7 (‑21.1, ‑4.4) | <.01 | |
| ADL | BMAC | 39 | 63.6 ± 2.946 | 40 | 79.2 ± 3.053 | .17 | <.01 | .58 | ‑5.5 (‑22.5, ‑8.6) | <.01 |
| MFAT | 33 | 57.2 ± 3.202 | 32 | 75.6 ± 3.401 | – | – | – | ‑18.4 (‑26.1, ‑10.7) | <.01 | |
| Sport/recreation | BMAC | 29 | 28.6 ± 4.224 | 26 | 56.1 ± 5.831 | .15 | <.01 | .79 | ‑27.5 (‑40.2, ‑14.8) | <.01 |
| MFAT | 24 | 21.3 ± 4.634 | 22 | 46.3 ± 6.333 | – | – | – | ‑25.0 (‑39.0, ‑11.0) | <.01 | |
| QOL | BMAC | 39 | 28.6 ± 2.995 | 40 | 52.0 ± 3.858 | .70 | <.01 | .45 | ‑23.4 (‑31.7, ‑15.1) | <.01 |
| MFAT | 32 | 29.4 ± 3.302 | 32 | 48.0 ± 4.303 | – | – | – | ‑18.6 (‑27.9, ‑9.3) | <.01 | |
Abbreviations: ADL, activities of daily living; BMAC, bone marrow aspirate concentrate; CI, confidence interval; MFAT, microfragmented adipose tissue; QOL, quality of life; VAS, Visual Analog Scale.