Table 3.
Comparison between patients with idiopathic PAH based on RV dyssynchrony.
| Variables | Lower tertiles (n = 39) | Intermediate tertiles (n = 39) | Upper tertiles (n = 38) | p-Value |
|---|---|---|---|---|
| Age (years) | 34 ± 10 | 31 ± 10 | 31 ± 11 | 0.402 |
| WHO-FC | 0.031 | |||
| I, II (n, %) | 23 (59.0) | 15 (38.5) | 13 (34.2) | |
| III, IV (n,%) | 16 (41.0) | 24 (61.5) | 25 (65.8) | |
| 6MWD (m) | 439 ± 77 | 415 ± 82 | 411 ± 87 | 0.306 |
| NT-proBNP (fmol/ml) | 1059.8 ± 691.1 | 1245.0 ± 734.6 | 1628.4 ± 939.6 | 0.008 |
| Echocardiographic parameters | ||||
| RVEDV (cm3) | 105.2 ± 37.0 | 108.6 ± 40.8 | 165.2 ± 63.1 | <0.001 |
| RVESV (cm3) | 70.2 ± 30.3 | 78.6 ± 32.5 | 124.9 ± 55.7 | <0.001 |
| RVEF (%) | 34.6 ± 9.4 | 28.0 ± 8.5 | 26.3 ± 9.6 | <0.001 |
| RVFAC (%) | 33.2 ± 9.8 | 29.1 ± 7.5 | 25.0 ± 4.9 | <0.001 |
| TAPSE (mm) | 17 ± 3 | 16 ± 3 | 15 ± 3 | 0.002 |
| LVEF (%) | 66.6 ± 6.3 | 63.9 ± 6.2 | 64.4 ± 7.7 | 0.202 |
| Hemodynamic parameters | ||||
| MRAP (mmHg) | 5 ± 4 | 6 ± 5 | 7 ± 5 | 0.191 |
| CI (l/min.m2) | 3.2 ± 1.0 | 2.7 ± 0.6 | 2.2 ± 0.6 | <0.001 |
| MPAP (mmHg) | 56 ± 18 | 58 ± 17 | 64 ± 17 | 0.131 |
| PVR (wood units) | 11.9 ± 6.1 | 14.1 ± 7.4 | 18.6 ± 7.5 | <0.001 |
Note: Data are presented as n (%) and mean ± SD. WHO-FC: World Health Organization functional class; 6MWD: 6-minute walking distance; TAPSE: tricuspid annular plane systolic excursion; LVEF: left ventricular ejection fraction; RVFAC: right ventricular fractional area change; RVEDV: right ventricular end-diastolic volume; RVESV: right ventricular end-systolic volume; RVEF: right ventricular ejection fraction; MRAP: mean right atrial pressure; MPAP: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; CI: cardiac index.