Table 1.

Questions for Future Research

Questions	Possible Methods of Investigation
1) If stress vulnerability can be thought of as reduced capacity to handle events, why does NA emerge when this capacity is exceeded? Are there are other signs that a limited capacity has been exceeded, besides NA? What are the neurocircuits which carry this load?	Animal models, neuroimaging studies, stress and emotion challenges, experience sampling methodologies, computational modeling
2) What are the developmentally sensitive periods for the emergence of NA associated with the development of psychosis?	Longitudinal studies including critical developmental periods, animal models
3) What is the relationship between vulnerability and cognition? Between vulnerability and negative symptoms?	Clinical phenotyping and analytics, eg, network analysis, structural equation modeling, causal modeling, etc.
4) If cognitive function is improved, can NA be properly regulated?	Cognitive behavior therapy for psychosis, cognitive training, pharmacologic cognitive enhancers
5) How can we separate NA related to a GABAergic (PVI) deficit from other causes of NA?	Multimodal neuroimaging and EEG with pharmacologic challenge; animal models
6) How much of the vulnerability in schizophrenia is shared across other disorders?	Transdiagnostic studies (including postmortem samples), genetic markers (polygenic risk scores)