Table 3.
NCRS domain | Cortical measure | Cluster | Size (mm2) | CWP | Peak coordinates (Tal X, TalY, TalZ) |
Motor symptoms | Cortical thickness | Left superior frontal gyrus | 1562.63 | 0.006 | –9.0, 26.7, 31.9 |
Left insula | 1362.78 | 0.017 | 37.2, 3.4, –0.4 | ||
Cortical area | Left superior frontal gyrus | 6911.45 | 0.0001 | –7.0, 19.8, 51.8 | |
Left lateral occipital gyrus | 3083.61 | 0.002 | –22.2, –96.1, –6.7 | ||
Right precentral gyrus (M1) | 3510.3 | 0.0007 | 32.9, –19.1, 54.1 | ||
Right fusiform gyrus | 2979.73 | 0.003 | 28.0, –73.5, –2.6 | ||
Right posterior cingulate gyrus | 1988.46 | 0.042 | 7.9, –22.4, 27.9 | ||
Cortical folding | Left inferior temporal gyrus | 2264.98 | 0.0001 | –52.8, –53.8, –3.3 | |
Left pericalcarine gyrus | 1490.06 | 0.0006 | –11.7, –89.4, 1.2 | ||
Left superior parietal gyrus | 1485.72 | 0.0006 | –22.4, –58.1, 52.0 | ||
Left precentral gyrus (M1) | 1189.12 | 0.003 | –45.4, –7.5, 46.4 | ||
Left lateral occipital gyrus | 819.97 | 0.045 | –43.2, –76.5, 5.8 | ||
Right superior parietal gyrus | 6610.06 | 0.0001 | 23.9, –41.9, 59.1 | ||
Right superior frontal gyrus | 1647.26 | 0.0002 | 20.1, –3.2, 53.8 | ||
Right inferior frontal gyrus (po) | 962.11 | 0.018 | 47.7, 20.2, 8.1 | ||
Affective symptoms | Cortical area | Left pericalcarine gyrus | 2496.3 | 0.014 | –14.1, –79.6, 10.5 |
Right pericalcalcarine gyrus | 3338.78 | 0.001 | 15.4, –73.9, 14.6 | ||
Behavioral symptoms | Cortical thickness | Right precentral gyrus (M1) | 4507.69 | 0.0001 | 46.9, 0.6, 33.0 |
Cortical area | Left precentral gyrus (M1) | 3328.08 | 0.001 | –48.6, –7.2, 41.4 | |
Right superior frontal gyrus | 5173.09 | 0.0001 | 22.2, 20.7, 37.7 | ||
Cortical folding | Left supramarginal gyrus | 819.17 | 0.043 | –58.7, –31.6, 36.0 | |
Right inferior parietal gyrus | 1384.87 | 0.0009 | 38.1, –48.2, 38.1 | ||
Right pericalcarine gyrus | 3364.83 | 0.0001 | 12.9, –83.2, 5.1 |
Significant clusters in both hemispheres: cluster size in mm², P values from the Monte Carlo simulation (P < .05) and clustering as cluster-wise probability (CWP), resulting from the vertex-wise comparison of mean cortical thickness, area and local gyrification index and NCRS scores. Age, gender, olanzapine equivalents, Positive and Negative Symptoms Scale, Abnormal involuntary movement scale, and Barnes Akathisia Rating Scale scores were used as covariates. Significant clusters that survived the Bonferroni correction (P < .0027) are displayed in bold font.