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. 2019 Feb 16;45(6):1257–1266. doi: 10.1093/schbul/sby191

Fig. 1.

Fig. 1.

Blood exosomal miRNA changes in patients with SCZ. (A) Serum exosome observation by electron microscopy and ×7000 magnification. (B) Western blots show the exosomal marker Alix and Flotillin-1 were present in the exosomes extracted from blood. (C) Western blots show that endoplasmic reticulum marker CNX and Golgi marker GP-73 were not present in the peripheral blood exosomes. (D) Serum exosome validation by nanoparticle tracking device—ZetaView. Note that the particles peak around at 100 nm. (E) MA-plot displaying miRNA differences between cases and controls for the training set of participants. (F) MA-plot for the testing set of participants. (G) MA-plot for pooled set of participants. (H) Significantly changed blood exosomal miRNA expression in the 49 cases as compared with 46 controls. CNX, Calnexin; GP-73, Golgi protein-73.