Fig. 1.

Pathways overrepresented in the list of differentially expressed genes in human microvascular endothelial cells treated with palmitate compared to BSA control. Top level pathways are represented by central nodes, with nodes in the outer rings representing sub-pathways. Relationships between nodes are represented by arcs (edges). Significantly (p < 0.05) overrepresented (enriched) pathways and relationships are indicated by increasing yellow signal. Black boxes in Fig. 1, Fig. 2, Fig. 3 highlight the top-level pathways and associated sub-pathways identified to have significant overrepresentation in all 3 comparisons. Reactome identifiers, pathway names, and genes identified in significantly overrepresented pathways are provided in Supplementary material.