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. 2019 Sep 5;28:101318. doi: 10.1016/j.redox.2019.101318

Table 2.

CoA preferentially binds to active, T288 phosphorylated Aurora A. The binding of T288 phosphorylated Aurora A (‘active’), or unphosphorylated Aurora A (‘inactive’), was assessed for each compound and the inhibitory constants were calculated. The data confirm that both the pantetheine and the 3′-phosphate of CoA participate in the interaction between Aurora A and CoA.

Compound Aurora A (active) IC50 (μM), binding assay Aurora A (inactive) IC50 (μM), binding assay Aurora A (active) IC50 (μM), activity assay
ATP 0.2 3.0 –
ADP 0.17 1.3 54
dpCoA 0.0003 >100 17
CoA 0.00001 0.28 5