Fig. 6.

Association of the baseline mitochondrial bioenergetics with Vehicle Control and Dox treated metabolome. A. xMWAS network of the vehicle treated platelets revealed 4 metabolic communities. Community 1 (orange) has features predominantly associated with reserve capacity, while community 2 (blue) has metabolic features associated with maximal respiration. Community 3 (yellow) has features associated with both basal and ATP-linked respiration. Community 4 (green) has features are associated with non-mitochondrial respiration as well as proton leak B. xMWAS network of the Dox treated platelet metabolome and bioenergetics revealed 3 metabolic communities. Community 1 (yellow) associated with basal and ATP linked OCR. Community 2 (gray) associated with both non-mitochondrial and reserve capacity. Community 3 (blue) associated with maximal respiration. (|r| > 0.6 at p < 0.05). Molecular features are depicted as circles and bioenergetic parameters as squares. Red lines indicate positive associations, and blue lines indicate negative associations. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)