Table 3.
Unidentified Metabolic Features which are highly enriched with Dox Treatment.
| No | m/z | RT (s) | Chemical_ID | Annotation Score | Formula | Name | Adduct | P value | Fold Change |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 542.1663 | 58 | C01661 | 4 | C27H29NO11 | Doxorubicin | M-H | 4.16E-11 | ∞ |
| 2 | 544.1723 | 58 | C01661 | 4 | C27H29NO11 | Doxorubicin | M-H [+2] | 1.37E-19 | ∞ |
| 3 | 377.067 | 59 | 5 | C21H14O7 | Doxorubicin Impurity 14 | M-H | 2.21E-18 | ∞ | |
| 4 | 395.0773 | 57 | 5 | C21H18O9 | Doxorubicinone | M-H2O–H | 3.52E-16 | ∞ | |
| 5 | 335.0547 | 183 | Unknown | Unknown | Unknown | Unknown | Unknown | 5.67E-12 | ∞ |
| 6 | 336.0594 | 179 | Unknown | Unknown | Unknown | Unknown | Unknown | 7.16E-14 | ∞ |
| 7 | 396.0808 | 59 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.56E-17 | ∞ |
| 8 | 397.0829 | 56 | Unknown | Unknown | Unknown | Unknown | Unknown | 5.36E-16 | ∞ |
| 9 | 407.3167 | 207 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.68E-11 | ∞ |
| 10 | 415.013 | 58 | Unknown | Unknown | Unknown | Unknown | Unknown | 1.13E-13 | ∞ |
| 11 | 416.0165 | 62 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.03E-16 | ∞ |
| 12 | 543.1697 | 59 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.01E-11 | ∞ |
| 13 | 578.1447 | 54 | Unknown | Unknown | Unknown | Unknown | Unknown | 1.12E-17 | ∞ |
| 14 | 579.1476 | 54 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.03E-17 | ∞ |
| 15 | 580.1391 | 50 | Unknown | Unknown | Unknown | Unknown | Unknown | 1.18E-17 | ∞ |
| 16 | 600.128 | 56 | Unknown | Unknown | Unknown | Unknown | Unknown | 5.53E-16 | ∞ |
| 17 | 601.1287 | 54 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.66E-16 | ∞ |
| 18 | 602.1213 | 53 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.97E-16 | ∞ |
| 19 | 603.1251 | 54 | Unknown | Unknown | Unknown | Unknown | Unknown | 3.45E-15 | ∞ |
| 20 | 610.1559 | 62 | Unknown | Unknown | Unknown | Unknown | Unknown | 1.14E-08 | ∞ |
| 21 | 616.1 | 54 | Unknown | Unknown | Unknown | Unknown | Unknown | 4.14E-17 | ∞ |
| 22 | 618.096 | 56 | Unknown | Unknown | Unknown | Unknown | Unknown | 2.26E-19 | ∞ |
| 23 | 674.0603 | 52 | Unknown | Unknown | Unknown | Unknown | Unknown | 9.92E-13 | ∞ |
Table 3 demonstrates differentially expressed metabolic features which were found to be highly enriched in the Dox treated group, but were not present in the Vehicle Control. ∞ indicates metabolites detected in Dox treated group but not in the baseline group (control).