Specifications Table

Subject area	Biology
More specific subject area	Pharmacology, Pain
Type of data	Figure
How data was acquired	Behavioral testing in animals with manual quantification. LC-20AC HPLC system coupled to a triple quad 6500 + mass spectrometer (HPLC-QqQ-MS) equipped with a Turbo V ion source (AB Sciex, Singapore) was used for pharmacokinetics. Analyst™ 1.7.1 software (Applied Biosystems, Foster City, CA) was applied to data collection, processing, and analysis.
Data format	Raw and analyzed
Experimental factors	The blood microdialysis probe is with 4 mm effective membrane length; 20,000 molecular weight cut-off and was positioned within the jugular vein toward the right atrium and then perfused with anti-coagulant citrate dextrose solution consisting of citric acid 3.5 mM, sodium citrate 7.5 mM, and dextrose 13.6 mM. The brain microdialysis probe was implanted in the corpus striatum zone and perfused with Ringer's solution (consisting of NaCl 145.3 mM; KCl 4.01mM; CaCl2 2.97 mM; pH 7.0) at 1.5 μl/min.
Experimental features	For assessment of potential side effects, the total travel distance, number of rearing behaviors, the duration of passivity and rectal temperature were recorded.
Data source location	Beijing, China.
Data accessibility	The data was attached with this article.
Related research article	T. Gao, T. Shi, Z. Wiesenfeld-Hallin, T. Li, J.-D. Jiang, X.- J. Xu, 2019. Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. Eur. J. Pharmacol., 854,101–108. https://doi.org/10.1016/j.ejphar.2019.03.061 [1].