Fig. 6.

Hippocampal electrophysiological function is altered in aging G6PD-deficient mice. Upper panel: Increased presynaptic function in aging hemizygous (def/y) G6PD-deficient male mice. Paired-pulse facilitation ratios (second fEPSP/first fEPSP) were plotted as a function of the interpulse intervals between the two stimulations, showing a significant enhancement in PPF in the aged G6PD-deficient mice compared to G6PD-normal wild-type controls (p < 0.05). Middle panel: Enhanced basal synaptic transmission in aging hemizygous G6PD-deficient male mice. The slope of evoked field excitatory postsynaptic potentials (fEPSPs) was plotted as a function of stimulus intensity, showing significant increases in both the slope and maximal responses in G6PD deficient mice compared to the age-matched G6PD-normal wild-type control (p < 0.05). The distance between the stimulating and recording electrodes was kept constant between slices and mice. Lower panel: Normal long-term potentiation (LTP) in aging hemizygous G6PD-deficient male mice. LTP was induced by theta burst stimulation (TBS) and showed no differences between genotypes. Traces in the inset above the graph were taken from the recordings immediately before and 40 min after delivery of the TBS given at a 20 min time point. The data were analyzed by Student's t-test.