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. 2019 Sep 17;28:101329. doi: 10.1016/j.redox.2019.101329

Fig. 1.

Fig. 1

IUOx protects against diet-induced obesity and insulin resistance in adulthood. A) Embryonic weight of male Ldlr −/− Sod2 + / + offspring at 18.5 days. N > 12/group. B) Oxidative stress marker 8-isoPGF2α in plasma of male Ldlr −/− Sod2 + / + offspring at 18.5 days (n = 6/group). Data are given as median and interquartile range. Mann-Whitney U test. C) Body weight trajectories from the start of Western diet feeding until 24 weeks of age. D) Glucose tolerance test in 12 week old offspring fed chow diet. E) Glucose tolerance test at 24 weeks, after 12 weeks on Western diet. Repeated measures ANOVA posthoc Fischer's exact test. F) Glucose-induced insulin secretion after 12 weeks of Western diet and HOMA-IR after 12 weeks on WD. Data are given as median and interquartile range; males, n = 4–5/group. Mann-Whitney U test. *p < 0.05, **p < 0.01.