Fig. 8.

MNPQ-mediated senolytic and senostatic activity during hydrogen peroxide-promoted senescence in BJ human fibroblasts in vitro. MNPQ treatment resulted in the elimination of oxidant-induced senescent cells (senolytic action) and suppression of proinflammatory responses (decreased secretion of IL-8 as a part of SASP response and decreased secretion of IFN-β as a part of interferon response) (senostatic action). The observed effects were accompanied by increased activity of AMPK (increased ratio of phosphorylated AMPK to AMPK).