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. 2019 Sep 27;6:2305–2321. doi: 10.1016/j.mex.2019.09.031
Subject Area: Chemistry
More specific subject area: Medicinal Chemistry
Protocol name: A practical synthesis of a novel DPAGT1 Inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies
Reagents/tools: All were operated with standard tools available in general synthetic and biochemistry lab.
Experimental design: All synthetic steps were demonstrated in gram-quantity. Selectivity of all asymmetric reactions is greater than 15:1 ratio.
Trial registration: N/A
Ethics: N/A