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Schematic on the tissue-selective processing of proglucagon. PCSK1: prohormone convertase 1/3; PCSK2: prohormone convertase 1/3; NTS: nucleus tractus solitarii; GRPP: glicentin-related polypeptide; IP-1 intervening peptide-1; IP-2: intervening peptide-2, MPGF: major proglucagon fragment; GLP-1: glucagon-like peptide-1; GLP-2: glucagon-like peptide-2. See text for further explanations.
