Skip to main content
. 2019 Sep 30;30:72–130. doi: 10.1016/j.molmet.2019.09.010

Figure 4.

Figure 4

Schematic on the GPCR Repertoire Involved in Control of Hormone Secretion from Gastric cells expressing either ghrelin or GLP-1. Green or red color background color indicates stimulation (green) or inhibition (red) of hormone secretion upon receptor activation. The colors of the receptors represent G protein signaling potential via G/s (green), G/q (orange) or G/i/o (red). The type of G protein responsible for the effect on hormone secretion has not been determined for all the receptors; for those where it has not been described, we have indicated the most likely coupling, based on data from other cell studies. 2-MAG, 2- monoacyl glycerol; BB2, bombesin receptor 2; Calcrl, calcitonin receptor-like receptor; CaSR, calcium sensing receptor; CGRP, calcitonin gene-related peptide; FACS, fluorescence-activated cell sorting; FFAR, free fatty acid receptor; GalR1, galanin receptor 1; GIP, glucose-dependent insulinotropic peptide; GIPR, GIP receptor; GPR, G protein receptor; MC$, melanocortin 4; MSH, melanocyte-stimulating hormone; NMC, neuromedin C; PYY, peptide YY; Ramp1, receptor activity modifying protein 1; SCTR, secretin receptor T; SSTR, somatostatin receptor; TGR5, bile acid receptor. Figure provided by the courtesy of Prof. T. W. Schwartz.