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Schematic on GLP-1 mediated insulin secretion in the β-cell. GLUT1/2: glucose transporter 1/2; AC: adenylate cyclase; PKA: protein kinase A; Epac2: exchange protein activated by cAMP; Pdx-1: pancreatic and duodenal homeobox 1; CICR: calcium-induced calcium release. For further explanations, please see text.
