Table 4.

Multivariable Model of Risk Factors to Predict Impaired Health-related Quality of Life Based on Pediatric Quality of Life Inventory Total Score in Patients with Normal Functional Status at Baseline (n = 341)^*

Variable	No. Patients [n (%)]	OR (95% CI)†	P Value
Factors present at hospital admission
Sociodemographic factors and preexisting health status
Age at PedsQL			0.0002
2–4 yr	144 (42)	1.0
5–7 yr	75 (22)	3.37 (1.47–7.75)
8–12 yr	60 (18)	5.51 (2.06–14.77)
13–17 yr	62 (18)	4.76 (2.31–9.82)
Non-Hispanic white	186 (55)	0.38 (0.20–0.72)	0.003
Cancer (current or previous diagnosis)	27 (8)	4.14 (1.80–9.50)	0.0008
Features of the presenting acute illness
PRISM III-12 score (1-point increase)	8 (5–13)‡	1.01 (0.98–1.04)	0.50
Hospital course variables
Inadequate sedation management§	69 (20)	3.15 (1.74–5.72)	0.0002

Definition of abbreviations: CI = confidence interval; OR = odds ratio; PedsQL = Pediatric Quality of Life Inventory; PRISM III-12 = Pediatric Risk of Mortality III score from the first 12 hours in the pediatric ICU.

^*Area under the curve = 0.761.

^†OR > 1 indicates higher risk of impaired health-related qualify of life. ORs were calculated using logistic regression accounting for pediatric ICU as a cluster variable using generalized estimating equations.

^‡Median (interquartile range).

^§Inadequate sedation management was defined as State Behavioral Scale score >0 (or agitation assumed present if receiving neuromuscular blockade) for 2 consecutive hours.