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. 2019 Oct 1;200(7):828–836. doi: 10.1164/rccm.201810-2050CP

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Copyright © 2019 by the American Thoracic Society

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). For commercial usage and reprints, please contact Diane Gern (dgern@thoracic.org).

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Figure 2. — Cumulative incidence functions for the primary event (extubation) in five ARDSNet (Acute Respiratory Distress Syndrome Clinical Network) trials. The subdistribution hazard ratio (SHR) and 95% confidence intervals are provided. Intervention (blue) and control (red) arms are displayed, and SHR greater than 1 is interpreted as greater hazard of intact extubation. ARMA (Respiratory Management in ARDS) and FACTT (Fluid and Catheter Treatment Trial) demonstrated a benefit of the intervention related to the probability of extubation, whereas OMEGA (Omega Nutritional Supplement Trial) demonstrated harm. ALTA = Albuterol for the Treatment of Acute Lung Injury; ALVEOLI = Assessment of Low Tidal Volume and Elevated End-expiratory Volume to Obviate Lung Injury; PEEP = positive end-expiratory pressure.