Figure 2.
BBR ameliorated PA-induced lipid accumulation in HK-2 cells via PPAR-a pathway. (A) mRNA and (B) protein levels of FAS, ACC, LPL, and CPT1 were assessed. ** P<0.01 versus Control; ## P<0.01 versus PA; ++ P<0.01 versus PA+BBR. BBR – berberine; PA – palmitic acid; PPAR – peroxisome proliferator-activated receptor a; FAS – fatty acid synthase; ACC – acetyl-CoA carboxylase; LPL – lipoprotein lipase; CPT1 – carnitine palmitoyl transferase 1.