Tables 5.

Effects of mania symptoms on vascular outcomes: linear mixed model analysis

	Model 1: Unadjusted				Model 2: Adjusted for age, gender, and psychotropic medication
Measure	β	SE	DF	P	β	SE	DF	P
Vascular Assessment
Flow-mediated dilation (%)	0.096	0.060	33	0.12	0.106	0.066	33	0.12
Nitroglycerine-mediated dilation (%)	0.061	0.062	33	0.34	0.056	0.065	33	0.40
Pulse wave velocity (m/s)	−0.004	0.013	45	0.77	0.006	0.013	45	0.67
Aortic systolic pressure (mmHg)	−0.046	0.102	45	0.66	0.018	0.100	45	0.85
Augmentation pressure (mmHg)	0.024	0.046	45	0.60	0.041	0.044	45	0.35
AIX@75 (mmHg)	0.177	0.115	45	0.13	0.222	0.112	45	0.053
FVR acetylcholine 30 μg/min response (%)	4.481	5.660	23	0.44	3.296	6.336	23	0.61
FVR nitroprusside 10 μg/min response (%)	8.840	4.068	23	0.04*	8.188	4.527	23	0.08
FVR verapamil 100 μg/min response (%)	4.702	3.970	21	0.25	3.321	4.606	21	0.48
Vital Signs and Labs
Systolic blood pressure (mmHg)	0.033	0.114	50	0.77	0.083	0.119	50	0.49
Diastolic blood pressure (mmHg)	0.216	0.096	50	0.03*	0.271	0.099	50	0.01*
Mean arterial pressure (mmHg)	0.156	0.090	50	0.09	0.205	0.093	50	0.03*
Pulse pressures (mmHg)	−0.114	0.103	50	0.27	−0.142	0.109	50	0.20
Heart rate (beats per minute)	0.103	0.120	50	0.40	0.077	0.125	50	0.54
HOMA-IR †	0.002	0.029	43	0.94	0.029	0.031	43	0.36
C-reactive protein (mg/L)	−0.040	0.067	40	0.55	−0.006	0.070	40	0.94
Triglycerides (mg/dl)	−0.782	1.063	44	0.47	0.514	1.106	44	0.64
LDL-c (mg/dl)	0.094	0.230	45	0.69	0.182	0.234	45	0.44
HDL-c (mg/dl)	−0.133	0.092	45	0.16	−0.087	0.092	45	0.35

^*P < 0.05

^†HOMA-IR is used to assess β- cell function and insulin resistance using fasting glucose and insulin concentrations.

AIX@75 = augmentation index adjusted for heart rate of 75; FVR = forearm vascular resistance; HOMA-IR = homeostatic model assessment for insulin resistance; LDL-c = low density lipoprotein-cholesterol; HDL-c =high density lipoprotein-cholesterol