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. Author manuscript; available in PMC: 2019 Oct 24.
Published in final edited form as: Mol Genet Genomics. 2019 Apr 17;294(4):1059–1071. doi: 10.1007/s00438-019-01567-7

Table 5.

Analysis of genotypic association of SCN4B variant G8S with VT under three different inheritance models

Cohorts
(n, cases vs. controls)		 Model Pobs OR (95% CI) Padj OR (95% CI)
VT cohort 1
(299 cases vs. 981 controls)		 Dominant 5.27E – 05 9.33 (2.95–29.52) 1.14E – 04 11.27 (3.29–38.57)
VT cohort 2
(270 cases vs. 639 controls)		 Dominant 0.007 4.37 (1.45–13.71) 0.032 3.67 (1.12–12.04)
VT combined
(569 cases vs.1620 controls)		 Dominant 1.30E – 06 6.52 (2.95–14.41) 2.84E – 05 6.27 (2.65–14.81)

Pobs P value observed, i.e., uncorrected P value by a Fisher’s exact test; Padj P value after adjustment with age and sex by multivariate logistic regression analysis for potential confounders; OR odds ratio, 95% CI 95% confidence interval