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Results from the TMLE analysis of the RTS,S/AS01 trial. Top: Multiple outputation TMLE estimates in vaccine and control groups of the incidence of clinical malaria cases matched (left) and mismatched (right) to the vaccine along the CS protein. Bottom left: Vaccine efficacy against matched (triangle) and mismatched (circle) infections. Bottom right: Vaccine sieve effect with 95% confidence intervals.
