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Micelle binding on discarded human tibial artery tissues with severe arterial calcification. Arteries incubated with HA PAMs or NT micelles were embedded, sectioned and stained with A) H&E and ARS (N=3). HA PAMs show strong signal and penetration through bulk calcification, while NT micelles have minimal signal. Scale bars 500 μm. B) HA PAMs exhibit strong colocalization (0.55 ± 0.09) with calcifications comapred to NTmicelles (0.24 ± 0.04). ** p≤0.01.
