Table 3.

Association between Disease Characteristics and Outcomes

		HR	OS [95% CI]	p-value	HR	RFS [95% CI]	p-value
All Surgical Patients
Complete Resection	Yes	0.25	[0.20 – 0.31]	<.001
	No
LN Status*	Positive	2.47	[1.83 – 3.35]	<.001
	Negative
Primary/Incidental	Incidental	0.51	[0.41 – 0.64]	<.001
	Primary
Neoadjuvant Chemotherapy	Yes	1.28	[0.79 – 2.06]	0.32
	No
Jaundice	Yes	2.60	[2.00 – 3.38]	<.001
	No
Complete Resection Patients
LN Status*	Positive	2.35	[1.67 – 3.31]	<.001	2.21	[1.59 – 3.07]	<.001
	Negative
Primary/Incidental	Incidental	0.66	[0.46 – 0.93]	0.019	0.65	[0.46 – 0.91]	0.012
	Primary
Neoadjuvant Chemotherapy	Yes	1.56	[0.79 – 3.07]	0.20	2.00	[1.08 – 3.72]	0.028
	No
Jaundice	Yes	3.09	[1.83 – 5.22]	<.001	2.46	[1.46 – 4.15]	<.001
	No
T-Stage	T3–T4	2.42	[1.74 – 3.37]	<.001	2.81	[2.04 – 3.87]	<.001
	T1b-T2
Margin	Positive	0.95	[0.23 – 3.82]	0.94	1.74	[0.55 – 5.47]	0.34
	Negative
Adjuvant Chemotherapy	Yes	1.33	[0.93 – 1.91]	0.12	1.28	[0.90 – 1.82]	0.17
	No