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. Author manuscript; available in PMC: 2020 Oct 23.
Published in final edited form as: J Am Chem Soc. 2019 Oct 15;141(42):16790–16801. doi: 10.1021/jacs.9b07396

Figure 1.

Figure 1.

(a) General mechanism of lanthipeptide biosynthesis. (b) Four classes of lanthipeptides based on their biosynthetic machineries. (c) olv gene cluster from Streptomyces olivaceus NRRL B-3009. (d) OlvA precursor peptide amino acid sequence with a GluC protease cleavage site used in this study highlighted. The highly conserved Asp residue is indicated with a green asterisk.